Colossal Biosciences and its woolly mouse are bringing vacation magic to the lab this yr, mixing festive storytelling with breakthrough science in an surprising manner.
In a whimsical Christmas video, the biotech firm turns a significant genetic milestone into a comfortable seasonal second.
The result’s a heartwarming introduction to a tiny creature carrying huge scientific significance.
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A Woolly Mouse Celebrates His First Christmas
The vacation season arrived early inside Colossal Biosciences’ labs with the discharge of a festive brief movie shared solely with PEOPLE.
Impressed by A Go to from St. Nicholas, the video reimagines the basic poem from the attitude of a really busy woolly mouse experiencing Christmas for the primary time.
Inside a warmly embellished house, the mouse darts previous stockings, climbs a glowing Christmas tree, and pauses to admire a wreath hanging above a miniature fire.
The tone is playful and storybook-like, however the star’s look instantly units him aside.
In contrast to a typical lab mouse, he sports activities longer, thicker, curlier fur harking back to traits as soon as discovered on prehistoric woolly mammoths.
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The video leans into that distinction, merging cozy visuals with scientific surprise earlier than closing on a cheerful message to viewers: “From Colossal’s lab to your wintry nights, blissful holidays to all … and to all woolly mice.”
Launched alongside an up to date vacation tune from Colossal, the video transforms a posh scientific achievement into one thing accessible, charming, and surprisingly emotional.
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The Science Behind The Woolly Mouse
Behind the festive visuals lies considered one of Colossal’s most talked-about milestones.
Earlier this yr, the corporate launched the woolly mouse as a proof level in its formidable mission to revive traits of the long-extinct woolly mammoth.
Whereas there was by no means a historic woolly mouse, researchers deliberately selected mice for his or her practicality and pace.
Elephants, the mammoth’s closest dwelling kin, have a 22-month gestation interval and take years to mature, making them impractical for early testing.
Mice, against this, have a gestation interval of roughly 20 days, permitting scientists to quickly examine how particular genes translate into bodily traits.
“I’m excited,” Colossal’s chief science officer Beth Shapiro instructed PEOPLE in an unique interview in March.
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She described the mouse as “actually our first validation” that the corporate can efficiently create dwelling animals with mammoth-inspired genetic traits.
“It’s the primary time that we’ve succeeded,” she added.
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Why Woolly Mouse Traits Matter
The woolly mouse was engineered with a number of cold-adapted traits utilizing mammoth gene orthologs.
These embody curlier hair comparable in shade to mammoth stays present in permafrost, together with genes linked to fats metabolism.
Collectively, the traits mirror variations that when allowed mammoths to outlive in frigid, resource-scarce environments.
Throughout her March interview, Shapiro defined that researchers would proceed observing the mice to see if they’re “really happier in cooler environments,” as supposed.
In response to a spokesperson, the woolly mice are at present “thriving and doing nice,” a reassuring replace for each scientists and followers who’ve adopted the challenge carefully.
For Colossal, the woolly mouse represents excess of a seasonal novelty.
It’s a managed demonstration of how genotype can affect phenotype, offering confidence that comparable methods may ultimately be utilized to bigger, extra advanced animals.
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Colossal Biosciences Blends Science And Storytelling
Colossal’s means to seize public consideration goes past genetic engineering.
The corporate has change into identified for pairing cutting-edge science with pop-culture-friendly storytelling that invitations curiosity fairly than intimidation.
The woolly mouse Christmas video is a transparent instance of that method, turning a lab achievement right into a narrative second folks wish to share.
Colossal Biosciences co-founder Ben Lamm underscored the broader implications in an unique chat with The Blast, saying, “The woolly mouse is an early demonstration of what’s doable when superior genetic engineering is utilized thoughtfully. Whereas it’s small in measurement, the implications for conservation analysis and de-extinction science are substantial.”
That philosophy has guided a number of of the corporate’s current public moments.
The occasion featured a dog-friendly cake and a music video written by Emmy Award–profitable musicians Stan Bush and Lenny Macaluso.
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The Future Past The Woolly Mouse
Past mammoths, Colossal is making progress on dodo chicken and thylacine, or Tasmanian tiger, initiatives.
Every effort is framed not as spectacle, however as a software for conservation, resilience, and moral reflection.
The woolly mouse suits squarely inside that framework, serving a selected function fairly than an open-ended experiment.
As for the woolly mice themselves, their function is restricted however significant.
“This isn’t a challenge that may go on indefinitely. It served a function of testing genotype to phenotype, which we bought optimistic outcomes,” Sara Ord, Colossal’s director of species restoration, beforehand instructed PEOPLE.
For now, the woolly mouse is having fun with his second within the vacation highlight.
Wrapped in twinkling lights and scientific risk, he represents a uncommon intersection of heat and surprise, proving that even the smallest creatures could make a giant impression when science meets storytelling.
